Interactions / Contraindications

Always talk with your doctor about previous health conditions, and other drugs (non-prescription and prescription) as well as any other vitamin supplements or herbal supplements before starting Prozac treatment. After taking Prozac for awhile it can stay in your system for up to a month. Knowing these interactions can help limit drug interactions between other drugs you might need to take.

SSRIs including Prozac should never be taken in conjunction with MAOIs (Monoamine Oxidase Inhibitors). Stop taking an MAOI 2-3 weeks before Prozac treatment and wait at least 5 weeks after Prozac treatment to take an MAOI again.
Do not take Prozac (Fluoxetine) in conjunction with any tricyclic anti-depressants.
Be careful ibuprofen and other NSAIDs, anti-platelet drugs such as clopidogrel, and wayfarin.
Aspirin can increase the risk of bleeding. Only continue usage if your doctor recommends it.
Do not use Prozac in conjunction with other drugs that act on serotonin such as St. John's Wort, 5-HTP, MDMA (Ecstasy), etc.

Do not take in conjunction with:
pimozide (Orap)
thioridazine (Mellaril)
carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
vinblastine (Velbe)
propafenone (Rythmol)
flecainide (Tambocor)
isocarboxazid (Marplan)
linezolid (Zyvox)
moclobemide (Aurorix, Manerix)
phenelzine (Nardil)
procarbazine (Matulane)
rasagiline (Azilect)
selegiline (Zelapar, etc)
tranylcypromine (Parnate)
eletriptan (Relpax)
sumatriptan (Imitrex)
citalopram (Celexa)
paroxetine (Paxil)
duloxetine (Cymbalta)
venlafaxine (Effexor)

This list is NOT exhaustive. Talk with your doctor about everything you take and are taking before starting Prozac treatment.

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